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KMID : 0861020070220010041
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Korea Journal of Herbology
2007 Volume.22 No. 1 p.41 ~ p.48
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Effects of a Mixture Ginseng Radix, Chaenomelis Fructus on the Mice Model of Alzheimer’s Disease
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Han Sin-Hee
Kil Ki-Jung
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Abstract
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Objectives : This research was investigated the effect of the Ginseng Radix plus Chaenomelis Fructus on Alzheimer’s disease.
Methods : Specifically, the effects of the Ginseng Radix plus Chaenomelis Fructus extract on IL-1{\beta}, TNF-{alpha} of BV2 microglia cell line treated with lipopolysacchride.
Results : The Ginseng Radix plus Chaenomclis Fructus extract suppressed the over-expression of IL-1{beta} protein, TNF-{alpha} protein, MDA, and CD68/CD11b, in the mice with Alzheimer’s disease induced by {beta} amyloid peptide.
Conclusion: These results suggest that the Ginseng Radix plus Chaenomelis Fructus extract may be effective for the prevention and treatment of Alzheimer’s disease. Investigation into the clinical use of the Ginseng Radix plus Chaenomelis Fructus extract for Alzheimer’s disease is suggested for future research.
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KEYWORD
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Ginseng Radix, Chaenomelis Fructus, Alzheimer’s disease
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